A novel combination of Soluplus® and Poloxamer for Meloxicam solid dispersions via hot melt extrusion for rapid onset of action—part 1: dissolution and stability studies

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Improving Dissolution of Meloxicam Using Solid Dispersions

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Improving Dissolution of Meloxicam Using Solid Dispersions

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

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ژورنال

عنوان ژورنال: Journal of Applied Pharmaceutical Science

سال: 2020

ISSN: 2231-3354

DOI: 10.7324/japs.2021.110218